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Image Search Results
Journal: American Journal of Respiratory Cell and Molecular Biology
Article Title: Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution
doi: 10.1165/rcmb.2018-0110OC
Figure Lengend Snippet: Plot of the cell type enrichment −log10 P value from the Genomic Annotation Shifter (GoShifter) analyses of the overlaps between emphysema distribution–associated genetic variants with DNase I–hypersensitive peaks, DNase I hotspots, enhancer marks, and digital DNase I footprints. The cell types with enrichment P values less than 0.05 are colored red in A and shown in more detail in B. iPS = induced pluripotent stem cell; PMA-I = phorbol 12-myristate 13-acetate plus ionomycin.
Article Snippet: We also examined
Techniques:
Journal: American Journal of Respiratory Cell and Molecular Biology
Article Title: Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution
doi: 10.1165/rcmb.2018-0110OC
Figure Lengend Snippet: Number of Cell Types with Overlaps between Emphysema Distribution–associated Genome-Wide Association Study Variants with Expression Quantitative Trait Loci in Lung, Blood, and Lymphoblastoid Cell Lines and Each or Any One of DNase I–Hypersensitive Sites, DNase Hotspots, Enhancer Regions, and DNase I Footprints
Article Snippet: We also examined
Techniques: Genome Wide, Expressing
Journal: BMC Bioinformatics
Article Title: A comparison of reference-based algorithms for correcting cell-type heterogeneity in Epigenome-Wide Association Studies
doi: 10.1186/s12859-017-1511-5
Figure Lengend Snippet: Epigenetic Dissection of Intra-Sample Heterogeneity: the EpiDISH algorithm. a Given a tissue of interest and with knowledge of the main underlying cell subtypes, EpiDISH constructs a reference DNA methylation (DNAm) database for these cell subtypes using (i) DNase Hypersensitive Sites (DHS) and DNAm data for these cell types from existing public databases and (ii) a supervised selection procedure which identifies differentially methylated CpGs (DMCs) among each pair of cell-types. The resulting reference DNAm database is defined only over DMCs that map to a DHS in at least one of the underlying cell-types. b Given a tissue sample of interest, EpiDISH next infers underlying cell type proportions/weights using robust partial correlations, with non-negativity and normalization constraints imposed a-posteriori. Having estimated cellular proportions for each sample, feature selection against a phenotype of interest is then performed using these proportions as covariates
Article Snippet: Here we present a novel framework for reference-based inference, which leverages
Techniques: Dissection, Construct, DNA Methylation Assay, Selection, Methylation